Officials say the woman was unconscious when firefighters rescued her from a second-floor bedroom. They attempted to perform CPR on her but could not revive her. She was pronounced dead at the scene.
The fire erupted around 1 a.m. in the 3700 Block of Cascadia Avenue South.
Firefighters were forced to evacuate the home when flames became too dangerous as the blaze entirely destroyed the two-story home.
No one else appeared to be injured.
Investigators are still working to determine the cause of the fire.